Role of memory T cell subsets for adoptive immunotherapy
نویسندگان
چکیده
منابع مشابه
Targeting p53 for adoptive T-cell immunotherapy.
p53 gene mutations occur in most human cancers and result in an altered protein product that accumulates within the cell. Although the observed endogenous human CTL response to p53 is weak, high-affinity, human p53-specific CTLs have been generated from HLA A2.1 transgenic mice immunized with human CTL epitope peptides. In this study, we examine the ability of HLA A2.1-restricted and human p53-...
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Cluster of differentiation (CD)8 T cells exist as naive, central memory, and effector memory subsets, and any of these populations can be genetically engineered into tumor-reactive effector cells for adoptive immunotherapy. However, the optimal subset from which to derive effector CD8 T cells for patient treatments is controversial and understudied. We investigated human CD8 T cells and found t...
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ژورنال
عنوان ژورنال: Seminars in Immunology
سال: 2016
ISSN: 1044-5323
DOI: 10.1016/j.smim.2016.02.001